Hemostasis, Thrombosis, and Vascular Biology

نویسندگان

  • Berthold Hoppe
  • Farzaneh Tolou
  • Hartmut Radtke
  • Holger Kiesewetter
  • Thomas Dörner
  • Abdulgabar Salama
چکیده

The factor VII–activating protease (FSAP) variant Marburg I is known to attenuate the profibrinolytic system in vitro and was recently shown to be a significant predictor for the evolution and progression of carotid stenosis. The objective of this case-control study was to assess FSAP Marburg I’s role in the occurrence of venous thromboembolism (VTE). The frequency of FSAP Marburg I was significantly increased in patients with a history of VTE (17 of 213 patients, 8.0%, P .014) or idiopathic VTE (12 of 103 patients, 11.7%, P .002) compared to healthy controls (5 of 213 controls, 2.3%). Logistic regression analysis confirmed FSAP Marburg I to be an independent risk factor for VTE (odds ratio, 3.5; 95% confidence interval [CI], 1.2-10.0) and idiopathic VTE (odds ratio, 6.2; 95% CI, 2.0-18.9). (Blood. 2005; 105:1549-1551)

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تاریخ انتشار 2005